Medicine Hat is at the centre of a number of routes and has excellent air, highway, and rail facilities.

The Medicine Hat Municipal Airport is served by both regional and national airlines. Air Canada /Air Canada Jazz operates four flights a day to Calgary using an 18 seat Beech 1900D aircraft.

Greyhound Bus Lines maintains a depot in downtown Medicine Hat.

Medicine Hat also has an integrated and accessible Transit service that runs throughout the community, six days a week.

Several local and regional courier companies serve Medicine Hat. Care Cabs Ltd., Deluxe Central Taxi, and Hat Taxi provide local taxi service. Medicine Hat is also home to several shuttle services.